Heparin sodium CAS 9041-08-1

Heparin sodium yog cov tshuaj tiv thaiv coagulant, uas yog cov tshuaj mucopolysaccharide.Nws yog sodium ntsev ntawm glucosamine sulfate muab rho tawm los ntawm cov hnyuv mucosa ntawm npua, nyuj thiab yaj.nruab nrab.Heparin sodium muaj lub luag haujlwm ntawm kev tiv thaiv platelet aggregation thiab kev puas tsuaj, inhibiting kev hloov ntawm fibrinogen rau hauv fibrin monomer, inhibiting tsim thromboplastin thiab tiv thaiv cov tsim thromboplastin, tiv thaiv kev hloov ntawm prothrombin rau thrombin thiab antithrombin.

Heparin sodium tuaj yeem ncua lossis tiv thaiv cov ntshav coagulation ob leeg hauv vitro thiab hauv vivo.Nws cov txheej txheem ntawm kev ua haujlwm yog qhov nyuaj heev thiab cuam tshuam rau ntau qhov sib txuas hauv cov txheej txheem coagulation.Nws cov haujlwm yog: ① inhibit tsim thiab ua haujlwm ntawm thromboplastin, yog li tiv thaiv prothrombin los ntawm kev ua thrombin;②Nyob rau hauv ntau dua, nws muaj peev xwm inhibit thrombin thiab lwm yam coagulation yam, tiv thaiv fibrinogen los ua fibrin Protein;③ tuaj yeem tiv thaiv kev sib sau thiab kev puas tsuaj ntawm platelets.Tsis tas li ntawd, cov nyhuv anticoagulant ntawm sodium heparin tseem cuam tshuam rau qhov tsis zoo ntawm sulfate radical hauv nws cov molecule.Kev them nyiaj zoo alkaline xws li protamine lossis toluidine xiav tuaj yeem ua rau nws cov nqi tsis zoo, yog li nws tuaj yeem cuam tshuam nws cov tshuaj tiv thaiv coagulant.coagulation.Vim tias heparin tuaj yeem qhib thiab tso tawm lipoprotein lipase hauv lub cev, hydrolyze triglyceride thiab qis lipoprotein tsawg hauv chylomicrons, yog li nws kuj muaj cov nyhuv hypolipidemic.

Heparin sodium tuaj yeem siv los kho cov kab mob thromboembolic, tshaj tawm cov kab mob hauv lub cev (DIC).Hauv xyoo tas los no, heparin tau pom tias muaj cov txiaj ntsig ntawm kev tshem tawm cov ntshav lipids.Intravenous txhaj los yog tob intramuscular txhaj (los yog subcutaneous txhaj), 5,000 mus rau 10,000 units txhua zaus.Heparin sodium yog qhov tsis muaj tshuaj lom thiab tsis muaj ntshav txaus yog qhov tseem ceeb tshaj plaws ntawm heparin overdose.Qhov ncauj tsis zoo, nws yuav tsum tau txhaj tshuaj.Kev txhaj tshuaj intramuscular lossis txhaj tshuaj subcutaneous yog qhov khaus ntau dua, qee zaus kev tsis haum tshuaj yuav tshwm sim, thiab kev siv tshuaj ntau dhau tuaj yeem ua rau mob plawv;qee zaus cov plaub hau poob thiab raws plab.Tsis tas li ntawd, nws tseem tuaj yeem ua rau pob txha tawg.Kev siv sijhawm ntev tuaj yeem ua rau mob thrombosis, uas tej zaum yuav yog qhov tshwm sim ntawm anticoagulase-III depletion.Heparin sodium yog contraindicated nyob rau hauv cov neeg mob uas los ntshav, mob siab heev thiab lub raum tsis ua hauj lwm, mob siab heev, hemophilia, intracranial hemorrhage, peptic rwj, cov poj niam cev xeeb tub thiab postpartum, visceral hlav, raug mob thiab phais.